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1

Recent advances in the metabolism of cannabinoids

Ikuo Yamamoto, Kazuhito Watanabe, Shizuo Narimatsu, Hidetoshi Yoshimura

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

1995

Language:

english

File:

PDF, 663 KB

english, 1995

2

Identification of cannabielsoin, a new metabolite of cannabidiol formed by guinea-pig hepatic microsomal enzymes, and its pharmacological activity in mice.

YAMAMOTO, Ikuo, GOHDA, Hiroshi, NARIMATSU, Shizuo, YOSHIMURA, Hidetoshi

Journal:

Journal of Pharmacobio-Dynamics

Year:

1988

File:

PDF, 708 KB

1988

3

Axonal degeneration and focal muscle fiber necrosis in human thallotoxicosis: Histopathological studies of nerve and muscle

Dr. Leonore C. Limos, Dr. Akio Ohnishi, Dr. Nozomi Suzuki, Dr. Noriaki Kojima, Dr. Takeo Yoshimura, Dr. Ikuo Goto, Dr. Yoshigoro Kuroiwa

Journal:

Year:

1982

Language:

english

File:

PDF, 2.19 MB

english, 1982

4

Cannabielsoin as a new metabolite of cannabidiol in mammals

Ikuo Yamamoto, Hiroshi Gohda, Shizuo Narimatsu, Kazuhito Watanabe, Hidetoshi Yoshimura

Journal:

Pharmacology Biochemistry and Behavior

Year:

1991

Language:

english

File:

PDF, 527 KB

english, 1991

5

8α,9α-Epoxyhexahydrocannabinol formation from Δ8-tetrahydrocannabinol by mouse liver microsomes

Ikuo Yamamoto, Shizuo Narimatsu, Kazuhito Watanabe, Hidetoshi Yoshimura

Journal:

Biochemical and Biophysical Research Communications

Year:

1982

Language:

english

File:

PDF, 294 KB

english, 1982

6

Distribution and characterization of anandamide amidohydrolase in mouse brain and liver

Kazuhito Watanabe, Hiroka Ogi, Shizuko Nakamura, Yuichiro Kayano, Tamihide Matsunaga, Hidetoshi Yoshimura, Ikuo Yamamoto

Journal:

Year:

1998

Language:

english

File:

PDF, 492 KB

english, 1998

7

Pharmacology and Toxicology of Major Constituents of Marijuana—On the Metabolic Activation of Cannabinoids and Its Mechanism

Yamamoto, Ikuo, Watanabe, Kazuhito, Matsunaga, Tamihide, Kimura, Toshiyuki, Funahashi, Tatsuya, Yoshimura, Hidetoshi

Journal:

Year:

2003

Language:

english

File:

PDF, 678 KB

english, 2003

8

The Median Atlanto-Occipital Joint in Advanced Age

Von Lüdinghausen, Michael, Prescher, Andreas, Kageya, Ikuo, Yoshimura, Ken

Journal:

Year:

2006

Language:

english

File:

PDF, 1.33 MB

english, 2006

9

9.ALPHA.,10.ALPHA.-Epoxyhexahydrocannabinol formation from .DELTA.9-tetrahydrocannabinol by liver microsomes of phenobarbital-treated mice and its pharmacological activities in mice.

NARIMATSU, SHIZUO, YAMAMOTO, IKUO, WATANABE, KAZUHITO, YOSHIMURA, HIDETOSHI

Journal:

Journal of Pharmacobio-Dynamics

Year:

1983

File:

PDF, 726 KB

1983

10

Synthesis of 8α, 9α- and 8β, 9β-Epoxyhexahydrocannabinols

YAMAMOTO, IKUO, NARIMATSU, SHIZUO, WATANABE, KAZUHITO, YOSHIMURA, HIDETOSHI

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1981

File:

PDF, 519 KB

1981

11

Synthesis and Pharmacological Evaluation in Mice of Halogenated Cannabidiol Derivatives.

USAMI, Noriyuki, OKUDA, Takeshi, YOSHIDA, Hisatoshi, KIMURA, Toshiyuki, WATANABE, Kazuhito, YOSHIMURA, Hidetoshi, YAMAMOTO, Ikuo

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1999

File:

PDF, 854 KB

1999

12

Light and Scanning Electron Microscopic Study on the Tongue and Lingual Papillae of the Japanese badgers, Meles meles anakuma

YOSHIMURA, Ken, SHINDO, Junji, KAGEYAMA, Ikuo

Journal:

Okajimas Folia Anatomica Japonica

Year:

2009

Language:

english

File:

PDF, 4.52 MB

english, 2009

13

Light and Scanning Electron Microscopic Study on the Tongue and Lingual Papillae of the Common Hippopotamus, Hippopotamus amphibius amphibius

Ken Yoshimura, Natsuki Hama, Junji Shindo, Kan Kobayashi, Ikuo Kageyama

Journal:

The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology

Year:

2009

Language:

english

File:

PDF, 868 KB

english, 2009

14

Light and Scanning Electron Microscopic Study on the Tongue and Lingual Papillae of the Common Hippopotamus, Hippopotamus amphibius amphibius

Ken Yoshimura, Natsuki Hama, Junji Shindo, Kan Kobayashi, Ikuo Kageyama

Journal:

The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology

Year:

2009

File:

PDF, 231 KB

2009

15

Preparation of connexin43-integrated giant Liposomes by a baculovirus expression–liposome fusion method

Koki Kamiya, Kanta Tsumoto, Satoko Arakawa, Shigeomi Shimizu, Ikuo Morita, Tetsuro Yoshimura, Kazunari Akiyoshi

Journal:

Biotechnology and Bioengineering

Year:

2010

Language:

english

File:

PDF, 2.97 MB

english, 2010

16

ChemInform Abstract: Synthesis and Pharmacological Activities in Mice of Halogenated Δ9-Tetrahydrocannabinol Derivatives.

Noriyuki Usami, Kiyofumi Kobana, Hisatoshi Yoshida, Toshiyuki Kimura, Kazuhito Watanabe, Hidetoshi Yoshimura, Ikuo Yamamoto

Journal:

Year:

1999

File:

PDF, 33 KB

1999

17

ChemInform Abstract: Synthesis and Pharmacological Evaluation in Mice of Halogenated Cannabidiol Derivatives.

Noriyuki Usami, Takeshi Okuda, Hisatoshi Yoshida, Toshiyuki Kimura, Kazuhito Watanabe, Hidetoshi Yoshimura, Ikuo Yamamoto

Journal:

Year:

2000

File:

PDF, 27 KB

2000

18

Fluorometric assay of microsomal aldehyde oxygenase activity: 9-anthraldehyde as a substrate

Kazuhito Watanabe, Manabu Ozaki, Tamihide Matsunaga, Ikuo Yamamoto, Hidetoshi Yoshimura

Journal:

Analytical Biochemistry

Year:

1991

Language:

english

File:

PDF, 617 KB

english, 1991

19

Ultraviolet photoelectron spectroscopy study of electronic states and deuterium adsorption on carbon nanowalls

Ikuo Kinoshita, Saori Hayashi, Hirofumi Yoshimura, Hiroshi Nakai, Masaru Tachibana

Journal:

Chemical Physics Letters

Year:

2008

Language:

english

File:

PDF, 351 KB

english, 2008

20

New syntheses of α-keto acid derivatives from nitriles using methyl methylthiomethyl sulfoxide

Katsuyuki Ogura, Nobuko Katoh, Ikuo Yoshimura, Gen-ichi Tsuchihashi

Journal:

Tetrahedron Letters

Year:

1978

Language:

english

File:

PDF, 214 KB

english, 1978

21

Accumulation of galactosylsphingosine (psychosine) does not interfere with phosphorylation and methylation of myelin basic protein in the twitcher mouse

Takeo Yoshimura, Takuro Kobayashi, Nobue Shinnoh, Ikuo Goto

Journal:

Neurochemical Research

Year:

1990

Language:

english

File:

PDF, 718 KB

english, 1990

22

Protein kinase C in rat brain myelin

Takeo Yoshimura, Takuro Kobayashi, Ikuo Goto

Journal:

Neurochemical Research

Year:

1992

Language:

english

File:

PDF, 925 KB

english, 1992

23

Inhibition of the proliferation of cultured immortalized schwann cells by forskolin with a decreased basal level of diacylglycerol

Takeo Yoshimura, Takuro Kobayashi, Shuichiro Goda, Ikuo Goto

Journal:

Neurochemical Research

Year:

1994

Language:

english

File:

PDF, 972 KB

english, 1994

24

Impact of chronic kidney disease on the severity of initially diagnosed coronary artery disease and the patient prognosis in the Japanese population

Hidenori Yagi, Makoto Kawai, Kimiaki Komukai, Takayuki Ogawa, Kosuke Minai, Tomohisa Nagoshi, Kazuo Ogawa, Hiroshi Sekiyama, Ikuo Taniguchi, Michihiro Yoshimura

Journal:

Heart and Vessels

Year:

2011

Language:

english

File:

PDF, 271 KB

english, 2011

25

Myasthenia gravis with diffuse alopecia areata and pemphigus foliaceus

Yasumori Izumi, Ikuo Kinoshita, Yoshiko Kita, Fumi Toriyama, Hideki Taniguchi, Masakatsu Motomura, Toshiro Yoshimura

Journal:

Journal of Neurology

Year:

2002

Language:

english

File:

PDF, 163 KB

english, 2002

26

Influence ofHelicobacter pyloriinfection on in vitro responsiveness of gastric fundus to agonists and to stimulation of enteric nerves in Mongolian gerbils

Yusuke Takehara, Yohei Mizuta, Hajime Isomoto, Ken Ohnita, Masaya Yoshimura, Takashi Nakamura, Fuminao Takeshima, Katsuhisa Omagari, Kunihiko Murase, Ikuo Murata, Kohtaro Taniyama, Shigeru Kohno

Journal:

Journal of Gastroenterology

Year:

2002

Language:

english

File:

PDF, 1.41 MB

english, 2002

27

Oral administration of coenzyme Q10reduces MPTP-induced loss of dopaminergic nerve terminals in the striatum in mice

Shota Kobayashi, Akiko Muroyama, Hiroaki Matsushima, Ikuo Yoshimura, Yasuhide Mitsumoto

Journal:

Neurological Sciences

Year:

2012

Language:

english

File:

PDF, 260 KB

english, 2012

28

Light and scanning electron microscopic study on the lingual papillae and their connective tissue cores of the Cape hyrax Procavia capensis

Ken Yoshimura, Natsuki Hama, Junji Shindo, Kan Kobayashi, Ikuo Kageyama

Journal:

Journal of Anatomy

Year:

2008

Language:

english

File:

PDF, 1.23 MB

english, 2008

29

Decreased Fatty Acylation of Myelin Proteolipid Protein in the Twitcher Mouse

Takeo Yoshimura, Takuro Kobayashi, Kunihiko Mitsuo, Ikuo Goto

Journal:

Journal of Neurochemistry

Year:

1989

Language:

english

File:

PDF, 1.02 MB

english, 1989

30

A Case of Acute Gastric Mucosal Lesions Associated with Helicobacter heilmannii Infection

Masaya Yoshimura, Hajime Isomoto, Saburo Shikuwa, Masayuki Osabe, Keiichiro Matsunaga, Katsuhisa Omagari, Yohei Mizuta, Kunihiko Murase, Ikuo Murata, Shigeru Kohno

Journal:

Year:

2002

Language:

english

File:

PDF, 4.83 MB

english, 2002

31

Analysis and pharmacotoxicity of feruloyltyramine as a new constituent and p-coumaroyltyramine in Cannabis sativa L.

Ikuo Yamamoto, Tamihide Matsunaga, Hiroe Kobayashi, Kazuhito Watanabe, Hidetoshi Yoshimura

Journal:

Pharmacology Biochemistry and Behavior

Year:

1991

Language:

english

File:

PDF, 350 KB

english, 1991

32

Difference in risk factors between acute coronary syndrome and stable angina pectoris in the Japanese: Smoking as a crucial risk factor of acute coronary syndrome

Hidenori Yagi, Kimiaki Komukai, Koichi Hashimoto, Makoto Kawai, Takayuki Ogawa, Ryuko Anzawa, Kosuke Minai, Tomohisa Nagoshi, Kazuo Ogawa, Ikuo Taniguchi, Michihiro Yoshimura

Journal:

Journal of Cardiology

Year:

2010

Language:

english

File:

PDF, 228 KB

english, 2010

33

Scoring of late gadolinium enhancement in cardiac magnetic resonance imaging can predict cardiac events in patients with hypertrophic cardiomyopathy

Ayumi Nojiri, Kenichi Hongo, Makoto Kawai, Kimiaki Komukai, Toru Sakuma, Ikuo Taniguchi, Michihiro Yoshimura

Journal:

Journal of Cardiology

Year:

2011

Language:

english

File:

PDF, 925 KB

english, 2011

34

Rapid identification of virus-carrying mosquitoes using reverse transcription-loop-mediated isothermal amplification

Namal Perera, Hiroka Aonuma, Aya Yoshimura, Tokiyasu Teramoto, Hiroshi Iseki, Bryce Nelson, Ikuo Igarashi, Takeshi Yagi, Shinya Fukumoto, Hirotaka Kanuka

Journal:

Journal of Virological Methods

Year:

2009

Language:

english

File:

PDF, 589 KB

english, 2009

35

Comparative morphological studies on the stereo structure of the lingual papillae of selected primates using scanning electron microscopy

Kan Kobayashi, Masahiko Kumakura, Ken Yoshimura, Masashi Takahashi, J.H. Zeng, Ikuo Kageyama, Keiichi Kobayashi, Natsuki Hama

Journal:

Annals of Anatomy - Anatomischer Anzeiger

Year:

2004

Language:

english

File:

PDF, 3.57 MB

english, 2004

36

Microsomal Alcohol Oxygenase: Purification and Characterization of a Cytochrome P450 Responsible for Oxidation of 7-Hydroxy-Δ8-tetrahydrocannabinol to 7-Oxo-Δ8-tetrahydrocannabinol in Guinea Pig Liver

Tamihide Matsunaga, Hiroyuki Tanaka, Akiko Komura, Kazuhito Watanabe, Ikuo Yamamoto, Hidetoshi Yoshimura

Journal:

Archives of Biochemistry and Biophysics

Year:

1997

Language:

english

File:

PDF, 211 KB

english, 1997

37

cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2, a microsomal aldehyde oxygenase

Tamihide Matsunaga, Kazuhito Watanabe, Ikuo Yamamoto, Masahiko Negishi, Frank J. Gonzalez, Hidetoshi Yoshimura

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

1994

Language:

english

File:

PDF, 254 KB

english, 1994

38

Purification of a cytochrome P450 isozyme belonging to a subfamily of P450 IIB from liver microsomes of guinea pigs

Shizuo Narimatus, Yuko Akutsu, Tamihide Matsunaga, Kazuhito Watanabe, Ikuo Yamamoto, Hidetoshi Yoshimura

Journal:

Biochemical and Biophysical Research Communications

Year:

1990

Language:

english

File:

PDF, 548 KB

english, 1990

39

Hepatic microsomal oxygenation of aldehydes to carboxylic acids

Kazuhito Watanabe, Shizuo Narimatsu, Ikuo Yamamoto, Hidetoshi Yoshimura

Journal:

Biochemical and Biophysical Research Communications

Year:

1990

Language:

english

File:

PDF, 272 KB

english, 1990

40

Mouse hepatic microsomal oxidation of aliphatic aldehydes (C8 to C011) to carboxylic acids

Kazuhito Watanabe, Tamihide Matsunaga, Shizuo Narimatsu, Ikuo Yamamoto, Hiddetoshi Yoshimura

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 319 KB

english, 1992

41

Effect of repeated administration of 11-hydroxy-Δ8-tetrahydrocannabinol, an active metabolite of Δ8tetrahydrocannabinol, on the hepatic microsomal drug-metabolizing enzyme system of mice

Watanabe Kazuhito, Aarai Mayumi, Narimatsu Shizuo, Yamamoto Ikuo, Yoshimura Hidetoshi

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 546 KB

english, 1986

42

Self-catalyzed inactivation of cytochrome P-450 during microsomal metabolism of cannabidiol

Kazuhito Watanabe, Mayumi Arai, Shizuo Narimatsu, Ikuo Yamamoto, Hidetoshi Yoshimura

Journal:

Biochemical Pharmacology

Year:

1987

Language:

english

File:

PDF, 679 KB

english, 1987

43

Formation of similar species to carbon monoxide during hepatic microsomal metabolism of cannabidiol on the basis of spectral interaction with cytochrome P-450

Watanabe Kazuhito, Narimatsu Shiuo, Gohda Hiroshi, Yamamoto Ikuo, Yoshimura Hidetoshi

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 821 KB

english, 1988

44

Catalytic activity of cytochrome P450 isozymes purified from rat liver in converting 11-oxo-Δ8-tetrahydrocannabinol to Δ8-tetrahydrocannabinol-11-oic acid

Kazuhito Watanabe, Tamihide Matsunaga, Shizuo Narimatsu, Ikuo Yamamoto, Susumu Imaoka, Yoshihiko Funae, Hidetoshi Yoshimura

Journal:

Biochemical Pharmacology

Year:

1991

Language:

english

File:

PDF, 673 KB

english, 1991

45

Sex difference in the oxidative metabolism of Δ9-tetrahydrocannabinol in the rat

Shizuo Narimatsu, Kazuhito Watanabe, Ikuo Yamamoto, Hidetoshi Yoshimura

Journal:

Biochemical Pharmacology

Year:

1991

Language:

english

File:

PDF, 651 KB

english, 1991

46

Immunochemical characterization of a cytochrome P450 isozyme and a protein purified from liver microsomes of male guinea pigs and their roles in the oxidative metabolism of Δ9-tetrahydrocannabinol by guinea pig liver microsomes

Shizuo Narimatsu, Yuko Akutsu, Tamihide Matsunaga, Kazuhito Watanabe, Ikuo Yamamoto, Hidetoshi Yoshimura

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 828 KB

english, 1992

47

A cytochrome P450 isozyme having aldehyde oxygenase activity plays a major role in metabolizing cannabinoids by mouse hepatic microsomes

Kazuhito Watanabe, Shizuo Narimatsu, Tamihide Matsunaga, Ikuo Yamamoto, Hidetoshi Yoshimura

Journal:

Biochemical Pharmacology

Year:

1993

Language:

english

File:

PDF, 778 KB

english, 1993

48

Involvement of protein kinase C in the proliferation of cultured Schwann cells

Takeo Yoshimura, Shuichiro Goda, Takuro Kobayashi, Ikuo Goto

Journal:

Year:

1993

Language:

english

File:

PDF, 553 KB

english, 1993

49

Comparison in mice of pharmacological effects of Δ8-tetrahydrocannabinol and its metabolites oxidized at 11-position

Kazuhito Watanabe, Ikuo Yamamoto, Kazuta Oguri, Hidetoshi Yoshimura

Journal:

European Journal of Pharmacology

Year:

1980

Language:

english

File:

PDF, 393 KB

english, 1980

50

Difference in tolerance development to hypothermia and pentobarbital-induced sleep prolongating effect of 11-hydroxy-Δ8-tetrahydrocannabinol and 11-oxo-Δ8-tetrahydrocannabinol in mice

Kazuhito Watanabe, Shizuo Narimatsu, Ikuo Yamamoto, Hidetoshi Yoshimura

Journal:

European Journal of Pharmacology

Year:

1982

Language:

english

File:

PDF, 221 KB

english, 1982

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